Evolving spike mutations in SARS-CoV-2 Omicron variants facilitate evasion from breakthrough infection-acquired antibodies

作者：Shiqi Chen, Zehong Huang, Yue Guo, Huilin Guo, Lijuan Jian, Jin Xiao, Xiangyang Yao, Hai Yu, Tong Cheng, Yali Zhang, Ming Guan, Richeng Mao, Jiming Zhang, Ningshao Xia, Quan Yuan · 发表于：Cell Discovery · 年份：2023 · DOI：10.1038/s41421-023-00584-6 · 被引用次数：19 · 研究领域：SARS-CoV-2 and COVID-19 Research、Monoclonal and Polyclonal Antibodies Research、Bacillus and Francisella bacterial research

SARS-CoV-2 inevitably evolves toward being more robust at multiplying. In the herd immunity era, mutations allowing SARS-CoV-2 to bypass the immunity acquired from vaccinations or infections may be essential in improving viral transmission fitness 1 , 2 , 3 , 4 , 5 . However, how evasion mutations drive the evolution remains to be elucidated.