Developing and validating a nomogram for cognitive impairment in the older people based on the NHANES

作者：Xiaoming Ma, Wendie Huang, Lijuan Lu, Hanqing Li, Jiahao Ding, Shiying Sheng, Meng Liu, Jie Yuan · 发表于：Frontiers in Neuroscience · 年份：2023 · DOI：10.3389/fnins.2023.1195570 · 被引用次数：10 · 研究领域：Dementia and Cognitive Impairment Research、Frailty in Older Adults、Neurological Disease Mechanisms and Treatments

Objective: To use the United States National Health and Nutrition Examination Study (NHANES) to develop and validate a risk-prediction nomogram for cognitive impairment in people aged over 60 years. Methods: A total of 2,802 participants (aged ≥ 60 years) from NHANES were analyzed. The least absolute shrinkage and selection operator (LASSO) regression model and multivariable logistic regression analysis were used for variable selection and model development. ROC-AUC, calibration curve, and decision curve analysis (DCA) were used to evaluate the nomogram's performance. Results: The nomogram included five predictors, namely sex, moderate activity, taste problem, age, and education. It demonstrated satisfying discrimination with a AUC of 0.744 (95% confidence interval, 0.696-0.791). The nomogram was well-calibrated according to the calibration curve. The DCA demonstrated that the nomogram was clinically useful. Conclusion: The risk-prediction nomogram for cognitive impairment in people aged over 60 years was effective. All predictors included in this nomogram can be easily accessed from its' user.