Neuroimaging, clinical and life course correlates of normal-appearing white matter integrity in 70-year-olds

作者：Sarah‐Naomi James, Emily N. Manning, Mathew Storey, Jennifer M. Nicholas, William Coath, Sarah E Keuss, David M. Cash, Christopher Lane, Thomas D. Parker, Ashvini Keshavan, Sarah M. Buchanan, Aaron Z. Wagen, Matthew Harris, Ian B. Malone, Kirsty Lu, Louisa P Needham, Rebecca E Street, David L. Thomas, John Dickson, Heidi Murray‐Smith, Andrew Wong, Tamar Freiberger, Sebastian J. Crutch, Nick C. Fox, Marcus Richards, Frederik Barkhof, Carole H. Sudre, Josephine Barnes, Jonathan M. Schott · 发表于：Brain Communications · 年份：2023 · DOI：10.1093/braincomms/fcad225 · 被引用次数：12 · 研究领域：Advanced Neuroimaging Techniques and Applications、Advanced MRI Techniques and Applications、Functional Brain Connectivity Studies

Abstract We investigate associations between normal-appearing white matter microstructural integrity in cognitively normal ∼70-year-olds and concurrently measured brain health and cognition, demographics, genetics and life course cardiovascular health. Participants born in the same week in March 1946 (British 1946 birth cohort) underwent PET-MRI around age 70. Mean standardized normal-appearing white matter integrity metrics (fractional anisotropy, mean diffusivity, neurite density index and orientation dispersion index) were derived from diffusion MRI. Linear regression was used to test associations between normal-appearing white matter metrics and (i) concurrent measures, including whole brain volume, white matter hyperintensity volume, PET amyloid and cognition; (ii) the influence of demographic and genetic predictors, including sex, childhood cognition, education, socio-economic position and genetic risk for Alzheimer’s disease (APOE-ɛ4); (iii) systolic and diastolic blood pressure and cardiovascular health (Framingham Heart Study Cardiovascular Risk Score) across adulthood. Sex interactions were tested. Statistical significance included false discovery rate correction (5%). Three hundred and sixty-two participants met inclusion criteria (mean age 70, 49% female). Higher white matter hyperintensity volume was associated with lower fractional anisotropy [b = −0.09 (95% confidence interval: −0.11, −0.06), P < 0.01], neurite density index [b = −0.17 (−0.22, −0.12), P ...