Patterns in Cancer Incidence Among People Younger Than 50 Years in the US, 2010 to 2019

作者：Benjamin Koh, Darren Jun Hao Tan, Cheng Han Ng, Clarissa Elysia Fu, Wen Hui Lim, Rebecca Wenling Zeng, Jie Ning Yong, Jia Hong Koh, Nicholas L. X. Syn, Wang Meng, Karn Wijarnpreecha, Ken Liu, Choon Seng Chong, Mark Dhinesh Muthiah, Hung Nguyen Luu, Arndt Vogel, Siddharth Singh, Khay Guan Yeoh, Rohit Seth Loomba, Daniel Q. Huang · 发表于：JAMA Network Open · 年份：2023 · DOI：10.1001/jamanetworkopen.2023.28171 · 被引用次数：213 · 研究领域：Global Cancer Incidence and Screening、Multiple and Secondary Primary Cancers、Acute Lymphoblastic Leukemia research

Importance: Emerging data suggest that the incidence of early-onset cancers, defined as cancers diagnosed in people younger than 50 years, is increasing, but updated data are limited. Objective: To characterize the patterns in the incidence of early-onset cancers in the US from 2010 to 2019 and provide granular data on the cancers with the fastest-growing incidence rates. Design, Setting, and Participants: This population-based cohort study analyzed data from 17 National Cancer Institute Surveillance, Epidemiology, and End Results registries from January 1, 2010, to December 31, 2019. Age-standardized incidence rates per 100 000 people were extracted for early-onset cancers, with rates age adjusted to the US standard population. A total of 562 145 patients with early-onset cancer between 2010 and 2019 were identified and included. Data were analyzed from October 16, 2022, to May 23, 2023. Main Outcomes and Measures: Primary outcomes were incidence rates and descriptive epidemiological data for people younger than 50 years with cancer. The annual percentage change (APC) of the age-standardized incidence rate was estimated using the Joinpoint regression program. Results: Among 562 145 patients (324 138 [57.7%] aged 40-49 years; 351 120 [62.5%] female) with early-onset cancer, 4565 (0.8%) were American Indian or Alaska Native, 54 876 (9.8%) were Asian or Pacific Islander, 61 048 (10.9%) were Black, 118 099 (21.0%) were Hispanic, 314 610 (56.0%) were White, and 8947 (1.6%) were o...