Single-cell sequencing provides insights into the landscape of ovary in PCOS and alterations induced by CUMS

作者：Wenting Zuo, Xiangfei Liu, Jianhuai Chen, Wenren Zuo, Yanyun Yin, Xiaowei Nie, Peipei Tang, Yunke Huang, Qian Yu, Qiaoyun Hu, Jie Zhou, Yong Tan, Xi Huang, Qingling Ren · 发表于：American Journal of Physiology-Endocrinology and Metabolism · 年份：2023 · DOI：10.1152/ajpendo.00165.2023 · 被引用次数：15 · 研究领域：Ovarian function and disorders、Reproductive System and Pregnancy、Ovarian cancer diagnosis and treatment

In this study, we mapped the landscape of polycystic ovary syndrome (PCOS) ovary with rat model induced by letrozole and provided a novel insight into the molecular mechanism of PCOS accompanied by chronic unpredicted mild stress (CUMS) at single-cell transcriptomic level. These observations highlight the importance of inflammation in the pathogenesis of PCOS, which might also be the bridge between PCOS and psychological diseases.