Single‐subject cortical morphological brain networks across the adult lifespan

作者：Jingxuan Ruan, Ningkai Wang, Junle Li, Jing Wang, Jing Wang, Qihong Zou, Yating Lv, Han Zhang, Jinhui Wang, Jinhui Wang · 发表于：Human Brain Mapping · 年份：2023 · DOI：10.1002/hbm.26450 · 被引用次数：29 · 研究领域：Functional Brain Connectivity Studies、Neural dynamics and brain function、Advanced Neuroimaging Techniques and Applications

Age-related changes in focal cortical morphology have been well documented in previous literature; however, how interregional coordination patterns of the focal cortical morphology reorganize with advancing age is not well established. In this study, we performed a comprehensive analysis of the topological changes in single-subject morphological brain networks across the adult lifespan. Specifically, we constructed four types of single-subject morphological brain networks for 650 participants (aged from 18 to 88 years old), and characterized their topological organization using graph-based network measures. Age-related changes in the network measures were examined via linear, quadratic, and cubic models. We found profound age-related changes in global small-world attributes and efficiency, local nodal centralities, and interregional similarities of the single-subject morphological brain networks. The age-related changes were mainly embodied in cortical thickness networks, involved in frontal regions and highly connected hubs, concentrated on short-range connections, characterized by linear changes, and susceptible to connections between limbic, frontoparietal, and ventral attention networks. Intriguingly, nonlinear (i.e., quadratic or cubic) age-related changes were frequently found in the insula and limbic regions, and age-related cubic changes preferred long-range morphological connections. Finally, we demonstrated that the morphological similarity in cortical thickness bet...