Public Attitudes About the Use of Gene Therapy in Mainland China

作者：Yiqi Li, Xinyue Zhang, Ze Xiang, Tianle Chen, Zihao Hu, Kexin Yang, Xinying Sun, Yibo Wu, Jian Wu · 发表于：JAMA Network Open · 年份：2023 · DOI：10.1001/jamanetworkopen.2023.28352 · 被引用次数：20 · 研究领域：BRCA gene mutations in cancer、CRISPR and Genetic Engineering、Health Systems, Economic Evaluations, Quality of Life

Importance: In addition to technical barriers, public attitudes about the use of gene therapy have an important association with the clinical implementation of gene therapy. Objective: To investigate the factors associated with public acceptance of gene therapy among individuals in China. Design, Setting, and Participants: This cross-sectional study used data from a survey conducted among 21 880 individuals in mainland China from June 20 to August 31, 2022. Main Outcomes and Measures: Stepwise linear regression was used to analyze factors associated with public acceptance of gene therapy in 5 key areas: basic personal information (gender, region, age, and educational level), family situation (marital status, children, and cousins), economic status (assets, debts, and insurance coverage), health knowledge (health literacy score and media use), and physical health status (chronic illness, cancer, European Quality of Life 5-Dimension 5-Level version [EQ-5D-5L] score, and Brief Illness Perception Questionnaire [BIPQ] score). Acceptance scores were calculated based on a visual analog scale (range, 0-100, with higher scores indicating higher acceptance of gene therapy). Further subgroup analysis was carried out in different age subgroups and populations with or without chronic diseases. Results: A total of 21 880 participants (mean [SD] age, 39.4 [18.9] years; 10 947 female participants [50.0%]; 10 933 male participants [50.0%]) were analyzed in this study. The mean (SD) acceptance...