Bioactive Indole Alkaloid from Aspergillus amoenus TJ507 That Ameliorates Hepatic Ischemia/Reperfusion Injury

作者：Yeting Zhang, Yeting Zhang, Xiangli Zhao, Yunfang Cao, Ming Chen, Zhengyi Shi, Meng–Huang Wu, Hao Feng, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Gang Chen, Changxing Qi, Yonghui Zhang, Yonghui Zhang · 发表于：Journal of Natural Products · 年份：2023 · DOI：10.1021/acs.jnatprod.3c00251 · 被引用次数：12 · 研究领域：Berberine and alkaloids research、Alkaloids: synthesis and pharmacology、Liver physiology and pathology

Hepatic ischemia/reperfusion injury (IRI) is a major factor contributing to the failure of hepatic resection and liver transplantation. As part of our ongoing investigation into bioactive compounds derived from fungi, we isolated eight indole alkaloids ( 1 – 8 ) from the endophytic fungus Aspergillus amoenus TJ507. Among these alkaloids, one previously undescribed compound, amoenamide D ( 1 ), was identified. The planar structure of 1 was elucidated by extensive spectroscopic analysis, including HRESIMS and NMR spectra. The absolute configuration of 1 was elucidated by using electronic circular dichroism calculations. Notably, in the CoCl 2 -induced hepatocyte damage model, notoamide Q ( 3 ) exhibited significant anti-hypoxia injury activity. Furthermore, in a murine hepatic ischemia/reperfusion injury model, treatment with 3 prevents IRI-induced liver damage and hepatocellular apoptosis. Consequently, 3 might serve as a potential lead compound to prevent hepatic ischemia/reperfusion injury.