Chirality: a key parameter in chemical probes

作者：Andrew McGown, Jordan Nafie, Mohammed Otayfah, Storm Hassell‐Hart, Graham J. Tizzard, Simon John Coles, Rebecca Banks, Graham P. Marsh, Hannah J. Maple, George E. Κostakis, Ilaria Proietti Silvestri, Paul J. J. Colbon, John A. Spencer · 发表于：RSC Chemical Biology · 年份：2023 · DOI：10.1039/d3cb00082f · 被引用次数：12 · 研究领域：DNA and Nucleic Acid Chemistry、Chemical Synthesis and Analysis、Protein Structure and Dynamics

administration of the wrong form of a drug. It is our firm belief that more stringent control of chirality be provided by the supplier and, if needed, requested by the end user, to minimise the potential issues mentioned above. Certification of chirality would bring much needed confidence in chemical structure assignment and could be provided by a variety of techniques, from polarimetry, chiral HPLC, using known chiral standards, vibrational circular dichroism, and x-ray crystallography. A few case studies of our brushes with wrong chirality assignment are shown as well as some examples of what we believe to be good practice.