Activation of Pyroptosis Using AIEgen-Based sp 2 Carbon-Linked Covalent Organic Frameworks

作者：Liang Zhang, Shu‐Cheng Wan, Jianyu Zhang, Mengjie Zhang, Qi‐Chao Yang, Boxin Zhang, Wuyin Wang, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam, Hexiang Deng, Zhi‐Jun Sun, Ben Zhong Tang · 发表于：Journal of the American Chemical Society · 年份：2023 · DOI：10.1021/jacs.3c04027 · 被引用次数：111 · 研究领域：Nanoplatforms for cancer theranostics、Luminescence and Fluorescent Materials、Heme Oxygenase-1 and Carbon Monoxide

Covalent organic frameworks (COFs) have emerged as a promising class of crystalline porous materials for cancer phototherapy, due to their exceptional characteristics, including light absorption, biocompatibility, and photostability. However, the aggregation-caused quenching effect and apoptosis resistance often limit their therapeutic efficacy. Herein, we demonstrated for the first time that linking luminogens with aggregation-induced emission effect (AIEgens) into COF networks via vinyl linkages was an effective strategy to construct nonmetallic pyroptosis inducers for boosting antitumor immunity. Mechanistic investigations revealed that the formation of the vinyl linkage in the AIE COF endowed it with not only high brightness but also strong light absorption ability, long lifetime, and high quantum yield to favor the generation of reactive oxygen species for eliciting pyroptosis. In addition, the synergized system of the AIE COF and αPD-1 not only effectively eradicated primary and distant tumors but also inhibited tumor recurrence and metastasis in a bilateral 4T1 tumor model.