Regulatory mechanisms and therapeutic implications of insulin-like growth factor 2 mRNA-binding proteins, the emerging crucial m6A regulators of tumors

作者：Heng Zhou, Qiang Sun, Ming-Liang Feng, Ziming Gao, Shiheng Jia, Lanxin Cao, Xue Yu, Shan Gao, Huizhe Wu, Kai Li · 发表于：Theranostics · 年份：2023 · DOI：10.7150/thno.86528 · 被引用次数：31 · 研究领域：RNA modifications and cancer、Cancer-related molecular mechanisms research、RNA Research and Splicing

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) serve essential biological functions as post-transcriptional performers, participating in the acquisition or maintenance of tumor hallmarks due to their distinct protein structures.Emerging evidence indicates that IGF2BPs belong to the class III type of RNA N 6 -methyladenosine (m 6 A) modification readers, controlling RNA stability, storage, localization, metabolism, and translation in multiple vital bioprocesses, particularly tumorigenesis and tumor progression.Here, we discuss the underlying regulatory mechanisms and pathological functions of IGF2BPs which act as m 6 A readers in the context of tumor pathogenesis and multidrug resistance.Furthermore, we highlight the potential of IGF2BPs as drug targets in clinical tumor treatment.Hence, precise and novel tumor therapeutic approaches could be uncovered by targeting epigenetic heterogeneity.