Cyclization of Azobenzenes Via Electrochemical Oxidation Induced Benzylic Radical Generation

作者：Anni Li, Xiangyi Li, Fang Ma, Hui Gao, Hongji Li · 发表于：Organic Letters · 年份：2023 · DOI：10.1021/acs.orglett.3c02099 · 被引用次数：26 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques

An electrochemical oxidation-induced cyclization of ortho -alkyl-substituted azobenzenes has been developed. The direct electrochemical benzylic C–H functionalization with respect to azobenzenes could proceed in the absence of any catalyst or external chemical oxidant to afford a number of 2 H -indazole derivatives in moderate to good yields. This protocol enables the reuse of the byproduct to the same 2 H -indazoles, thus significantly reducing pollution discharge in synthetic chemistry.