Associations among multidomain lifestyles, chronic diseases, and dementia in older adults: a cross-sectional analysis of a cohort study

作者：Jingjing Zhang, Zhaoxia Wu, Wei Tan, Dan Liu, Guirong Cheng, Lang Xu, Feifei Hu, Yan Zeng · 发表于：Frontiers in Aging Neuroscience · 年份：2023 · DOI：10.3389/fnagi.2023.1200671 · 被引用次数：8 · 研究领域：Dementia and Cognitive Impairment Research、Nutritional Studies and Diet、Chronic Disease Management Strategies

Background Unhealthy lifestyles and chronic diseases are commonly seen and treatable factors in older adults and are both associated with dementia. However, the synergistic effect of the interaction of lifestyles and chronic diseases on dementia is unknown. Methods We determined independent associations of multidomain lifestyles and chronic diseases (cerebrovascular disease, diabetes, and hypertension) with dementia and examined their synergistic impact on dementia among older adults. The data were drawn from the Hubei Memory and Aging Cohort Study. We created a summary score of six factors for multidomain lifestyles. Dementia was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders IV. Logistic regression and multiple correspondence analyses were used to explore the relationships among multidomain lifestyles, chronic diseases, and dementia. A sensitivity analysis was performed to minimize the interference of reverse causality and potential confounders. Results Independent associations with dementia were found in unhealthy (OR = 1.90, 95% CI: 1.38–2.61) and intermediate healthy lifestyles (OR, 3.29, 2.32–4.68), hypertension (OR, 1.21, 1.01–1.46), diabetes (OR, 1.30, 1.04–1.63), and cerebrovascular disease (OR, 1.39, 1.12–1.72). Interactions of diabetes ( p = 0.004), hypertension ( p = 0.004), and lifestyles were significant, suggesting a combined impact on dementia. Sensitivity analysis supported the strong association among multidomain lifestyles,...