FGF21 promotes myocardial angiogenesis and mediates the cardioprotective effects of exercise in myocardial infarction mice

作者：Wenyan Bo, Yixuan Ma, Lili Feng, Mengyuan Yu, Lili Zhang, Mengxin Cai, Wei Song, Yue Xi, Zhenjun Tian · 发表于：Journal of Applied Physiology · 年份：2023 · DOI：10.1152/japplphysiol.00307.2023 · 被引用次数：13 · 研究领域：Fibroblast Growth Factor Research、Kruppel-like factors research、Cancer, Hypoxia, and Metabolism

FGF21 activated FGFR1/PI3K/AKT/VEGF signaling pathway mediated angiogenesis in MI mice. FGF21 deficiency attenuated aerobic exercise-induced cardiac angiogenesis in MI mice. FGF21/FGFR1/PI3K/AKT/VEGF signal played an important role in aerobic exercise to promote myocardial angiogenesis and improved cardiac function.