A global action agenda for turning the tide on fatty liver disease

作者：Jeffrey Victor Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A. Alqahtani, Quentin Mark Anstee, Marco A. Arrese, Ramon A. Bataller, Thomas Berg, Paul Brennan, Patrizia Burra, Graciela Castro‐Narro, Helena Cortez‐Pinto, Kenneth J. Cusi, Nikos Dedes, Ajay Kumar. Duseja, Sven Francque, Amalia Gastaldelli, Hannes Hagström, Terry T.‐K. Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J. Kopka, Aleksander Ahm Krag, Philip Noel Newsome, Mary Eugenia Rinella, Diana Requena Romero, Shiv Kumar Sarin, Marcelo Silva, C Wendy Spearman, Norah A. Terrault, Emmanuel A. Tsochatzis, Luca V. C. Valenti, Marcela Villota‐Rivas, Shira Zelber‐Sagi, Jörn Markus Schattenberg, Vincent Wai‐Sun Wong, Zobair M. Younossi, on behalf of the Healthy Livers, Healthy Lives Collaborators · 发表于：Hepatology · 年份：2023 · DOI：10.1097/hep.0000000000000545 · 被引用次数：92 · 研究领域：Liver Disease Diagnosis and Treatment、Liver Disease and Transplantation、Hepatitis C virus research

BACKGROUND AND AIMS: Fatty liver disease is a major public health threat due to its very high prevalence and related morbidity and mortality. Focused and dedicated interventions are urgently needed to target disease prevention, treatment, and care. APPROACH AND RESULTS: We developed an aligned, prioritized action agenda for the global fatty liver disease community of practice. Following a Delphi methodology over 2 rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the action priorities using Qualtrics XM, indicating agreement using a 4-point Likert-scale and providing written feedback. Priorities were revised between rounds, and in R2, panelists also ranked the priorities within 6 domains: epidemiology, treatment and care, models of care, education and awareness, patient and community perspectives, and leadership and public health policy. The consensus fatty liver disease action agenda encompasses 29 priorities. In R2, the mean percentage of "agree" responses was 82.4%, with all individual priorities having at least a super-majority of agreement (> 66.7% "agree"). The highest-ranked action priorities included collaboration between liver specialists and primary care doctors on early diagnosis, action to address the needs of people living with multiple morbidities, and the incorporation of fatty liver disease into relevant non-communicable disease strategies and guidance. CONCLUSIONS: This consensus-driven multidisciplinary fatty liver disease action agenda developed by ca...