Time-efficient, high resolution 3T whole brain relaxometry using 3D-QALAS with wave-CAIPI readouts

作者：Borjan Gagoski, Jaejin Cho, Zijing Zhang, Tae Hyung Kim, Wei‐Ching Lo, Daniel Polak, Marcel Warntjes, Stephen Cauley, Kawin Setsompop, P. Ellen Grant, Berkin Bilgiç · 发表于：Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · 年份：2023 · DOI：10.58530/2022/4388 · 被引用次数：3 · 研究领域：Advanced MRI Techniques and Applications、Advanced NMR Techniques and Applications、Lanthanide and Transition Metal Complexes

Volumetric, high resolution, quantitative mapping of brain tissues’ relaxation properties is hindered by long acquisition times and signal-to-noise (SNR) challenges. This study, for the first time, combines the time-efficient wave-CAIPI readouts with the 3D-Quantification using an interleaved Look-Locker acquisition sequence with T 2 preparation pulse (3D-QALAS) scheme, enabling full brain quantitative T 1 , T 2 and proton density (PD) maps at 1.15 mm isotropic voxels in only 3 minutes at R=3x2 acceleration. When tested in both the ISMRM/NIST phantom and 7 healthy volunteers, the quantitative maps using the accelerated protocol showed excellent agreement against those obtained from conventional 3D-QALAS at R GRAPPA =2.