Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases

作者：Jinyao Liu, Shuang Liu, Mingyue Yu, Jianing Li, Zunxuan Xie, Boyang Gao, Yuyan Liu · 发表于：Drug Development Research · 年份：2023 · DOI：10.1002/ddr.22096 · 被引用次数：22 · 研究领域：Phytochemistry and Biological Activities、Essential Oils and Antimicrobial Activity、Phytochemical and Pharmacological Studies

Catalpol is a kind of iridoid glucoside, widely found in a variety of plants, mostly extracted from the rhizome of the traditional medicinal herb rehmanniae. It has various biological activities such as anti-inflammatory, antioxidant, and antitumor. The anti-inflammatory effects of catalpol have been demonstrated in a variety of diseases, such as neurological diseases, atherosclerosis, renal diseases, respiratory diseases, digestive diseases, bone and joint diseases, eye diseases, and periodontitis. The purpose of this review is to summarize the existing literature on the anti-inflammatory effects of catalpol in a variety of inflammatory diseases over the last decade and to focus on the anti-inflammatory mechanisms of catalpol.