Exploring the efficacy of herbal medicinal products as oral therapy for inflammatory bowel disease

作者：Min‐zheng Zhu, Meifeng Yang, Yang Song, Haoming Xu, Jing Xu, Ning-ning Yue, Yuan Zhang, Cheng‐mei Tian, Ruiyue Shi, Yu-jie Liang, Jun Yao, Lisheng Wang, Yuqiang Nie, Defeng Li · 发表于：Biomedicine & Pharmacotherapy · 年份：2023 · DOI：10.1016/j.biopha.2023.115266 · 被引用次数：24 · 研究领域：Inflammatory Bowel Disease、Inflammasome and immune disorders、Pharmacological Effects of Medicinal Plants

Inflammatory bowel disease (IBD) encompasses a collection of idiopathic diseases characterized by chronic inflammation in the gastrointestinal (GI) tract. Patients diagnosed with IBD often experience necessitate long-term pharmacological interventions. Among the multitude of administration routes available for treating IBD, oral administration has gained significant popularity owing to its convenience and widespread utilization. In recent years, there has been extensive evaluation of the efficacy of orally administered herbal medicinal products and their extracts as a means of treating IBD. Consequently, substantial evidence has emerged, supporting their effectiveness in IBD treatment. This review aimed to provide a comprehensive summary of recent studies evaluating the effects of herbal medicinal products in the treatment of IBD. We delved into the regulatory role of these products in modulating immunity and maintaining the integrity of the intestinal epithelial barrier. Additionally, we examined their impact on antioxidant activity, anti-inflammatory properties, and the modulation of intestinal flora. By exploring these aspects, we aimed to emphasize the significant advantages associated with the use of oral herbal medicinal products in the treatment of IBD. Of particular note, this review introduced the concept of herbal plant-derived exosome-like nanoparticles (PDENs) as the active ingredient in herbal medicinal products for the treatment of IBD. The inclusion of PDENs of...