Imaging application of an MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe

作者：X. K. Zhou, Changmei Zhang, Qiquan Zhou, Jian Liang, Xiaoyan Zhang, Yujie Shi, Jingna Zhu, Lei Zhong · 发表于：Journal of Biomaterials Applications · 年份：2023 · DOI：10.1177/08853282231194147 · 被引用次数：4 · 研究领域：Nanoplatforms for cancer theranostics、Advanced biosensing and bioanalysis techniques、Advanced Nanomaterials in Catalysis

In recent years, the application of nanoimaging technology on standardize tumor diagnosis has become a new research hotspot, especially nanoprobes. Our research group has synthesized a kind of nanocarrier, mPEG2000-GPLGIAGQ-DSPE, which has the characteristic of matrix metalloproteinase-2 (MMP2) sensitive ability in tumor microenvironment. Meanwhile, the encapsulation method is adopted to prepare MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe with mPEG2000-GPLGIAGQ-DSPE as the carrier. On the one hand, this novel nanoprobe not only can effectively improve the solubility of prussian blue, but is non-toxic and safe for cells. On the other hand, octapeptide (GPLGIAGQ) in mPEG2000-GPLGIAGQ-DSPE nanocarrier can specifically respond to MMP2 in tumor cells to release prussian blue, and achieve targeted intelligent imaging of tumor cells.