The role of functional and structural properties of the nucleus accumbens subregions in eating behavior regulation of bulimia nervosa

作者：Yiling Wang, Lirong Tang, Miao Wang, Guowei Wu, Weihua Li, Xuemei Wang, J. Wang, Zhenghan Yang, Xiaohong Li, Zhanjiang Li, Qian Chen, Peng Zhang, Zhenchang Wang · 发表于：International Journal of Eating Disorders · 年份：2023 · DOI：10.1002/eat.24038 · 被引用次数：9 · 研究领域：Eating Disorders and Behaviors、Emotion and Mood Recognition、Virtual Reality Applications and Impacts

OBJECTIVE: Although studies have demonstrated the involvement of the nucleus accumbens (NAc) in the neurobiology of eating disorders, its alterations in bulimia nervosa (BN) remain largely unknown. This study investigated the structural and functional properties of NAc in patients with BN. METHOD: Based on the resting-state functional MRI and high-resolution anatomical T1-weighted imaging data acquired from 43 right-handed BN patients and 40 sex-, age- and education-matched right-handed healthy controls (HCs), the group differences in gray matter volume (GMV) and fractional amplitude of low-frequency fluctuation (fALFF) in slow-4 and -5 bands and functional connectivity (FC) of NAc subregions (core and shell) were compared. The relationships between MRI and clinical data were explored in the BN group. RESULTS: Compared with HCs, BN patients showed preserved GMV, decreased fALFF in slow-5 band of the left NAc core and shell, decreased FC between left NAc core and right caudate, and increased FC between all NAc subregions and frontal regions, between all NAc subregions (except the right NAc core) and the supramarginal gyrus (SMG), and between right NAc shell and left middle temporal gyrus. FC between the NAc and SMG was correlated with emotional eating behaviors. DISCUSSION: Our study revealed preserved GMV, local neuronal activity reduction and functional network reorganization of the NAc in BN. The functional network reorganization of the NAc mainly occurred in the frontal co...