Estimating presymptomatic episodic memory impairment using simple hand movement tests: A cross‐sectional study of a large sample of older adults

作者：Xinyi Wang, Rebecca J. St George, Aidan Bindoff, Alastair J. Noyce, Katherine Lawler, Eddy Roccati, Larissa Bartlett, Son N. Tran, James C. Vickers, Quan Bai, Jane Alty · 发表于：Alzheimer s & Dementia · 年份：2023 · DOI：10.1002/alz.13401 · 被引用次数：15 · 研究领域：Dementia and Cognitive Impairment Research、Alzheimer's disease research and treatments、Balance, Gait, and Falls Prevention

INTRODUCTION: Finding low-cost methods to detect early-stage Alzheimer's disease (AD) is a research priority for neuroprotective drug development. Presymptomatic Alzheimer's is associated with gait impairment but hand motor tests, which are more accessible, have hardly been investigated. This study evaluated how home-based Tasmanian (TAS) Test keyboard tapping tests predict episodic memory performance. METHODS: 1169 community participants (65.8 ± 7.4 years old; 73% female) without cognitive symptoms completed online single-key and alternate-key tapping tests and episodic memory, working memory, and executive function cognitive tests. RESULTS: = 8.1%). No tapping features improved estimation of working memory. DISCUSSION: Brief self-administered online hand movement tests predict asymptomatic episodic memory impairment. This provides a potential low-cost home-based method for stratification of enriched cohorts. HIGHLIGHTS: We devised two brief online keyboard tapping tests to assess hand motor function. 1169 cognitively asymptomatic adults completed motor- and cognitive tests online. Impaired hand motor function predicted reduced episodic memory performance. This brief self-administered test may aid stratification of community cohorts.