Microglia–Astrocyte Interaction in Neural Development and Neural Pathogenesis

作者：Meiqi Sun, Hongli You, Xiaoxuan Hu, Yujia Luo, Zixuan Zhang, Yiqun Song, Jing An, Haixia Lü · 发表于：Cells · 年份：2023 · DOI：10.3390/cells12151942 · 被引用次数：87 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Neurogenesis and neuroplasticity mechanisms、Immune cells in cancer

The interaction between microglia and astrocytes exhibits a relatively balanced state in order to maintain homeostasis in the healthy central nervous system (CNS). Disease stimuli alter microglia-astrocyte interaction patterns and elicit cell-type-specific responses, resulting in their contribution to various pathological processes. Here, we review the similarities and differences in the activation modes between microglia and astrocytes in various scenarios, encompassing different stages of neural development and a wide range of neural disorders. The aim is to provide a comprehensive understanding of their roles in neural development and regeneration and guiding new strategies for restoring CNS homeostasis.