Prevalence, management and efficacy of treatment in portal vein obstruction after paediatric liver transplantation: protocol of the retrospective international multicentre PORTAL registry

作者：Bader A Alfares, Hubert P. J. van der Doef, Barbara E. Wildhaber, Thomas Casswall, Greg Nowak, Martin Delle, Denise Aldrian, Valeria Berchtold, Georg F. Vogel, Piotr Kaliciński, Małgorzata Markiewicz‐Kijewska, Adam Koleśnik, Jesús Q Bernabeu, María Mercadal Hally, Mauricio Larrarte King, Paolo Marra, M. Bravi, D. Pinelli, Mureo Kasahara, Seisuke Sakamoto, Hajime Uchida, Vidyadhar Padmakar Mali, Marion Aw, Stéphanie Franchi‐Abella, Emmanuel Gonzalès, Florent Guérin, Guillermo Cervio, Julia Minetto, Sergio Sierre, Martín de Santibañes, Victoria Ardiles, Jimmy Walker Uño, Helen Evans, David Duncan, John McCall, Steffen Hartleif, Ekkehard Sturm, Jai V. Patel, Marumbo Mtegha, Rajendra Prasad, Cristina Targa Ferreira, Luiza Salgado Nader, Marco Farina, Catalina Jaramillo, Manuel I. Rodríguez-Dávalos, Peter Feola, Amit A. Shah, Phoebe M Wood, Michael R. Acord, Ryan T. Fischer, Bhargava Mullapudi, Richard J. Hendrickson, Rajeev Khanna, Viniyendra Pamecha, Amar Mukund, Khalid Sharif, Girish Gupte, Simon P. McGuirk, Gilda Porta, Marco Spada, Tommaso Alterio, Giuseppe Maggiore, Winita Hardikar, Marisa Beretta, Rudi Dierckx, Ruben H.J. de Kleine, Reinoud P.H. Bokkers · 发表于：BMJ Open · 年份：2023 · DOI：10.1136/bmjopen-2022-066343 · 被引用次数：5 · 研究领域：Organ Transplantation Techniques and Outcomes、Liver Disease and Transplantation、Hepatocellular Carcinoma Treatment and Prognosis

INTRODUCTION: Portal vein obstruction (PVO) consists of anastomotic stenosis and thrombosis, which occurs due to a progression of the former. The aim of this large-scale international study is to assess the prevalence, current management practices and efficacy of treatment in patients with PVO. METHODS AND ANALYSIS: The Portal vein Obstruction Revascularisation Therapy After Liver transplantation registry will facilitate an international, retrospective, multicentre, observational study, with 25 centres around the world already actively involved. Paediatric patients (aged <18 years) with a diagnosed PVO between 1 January 2001 and 1 January 2021 after liver transplantation will be eligible for inclusion. The primary endpoints are the prevalence of PVO, primary and secondary patency after PVO intervention and current management practices. Secondary endpoints are patient and graft survival, severe complications of PVO and technical success of revascularisation techniques. ETHICS AND DISSEMINATION: Medical Ethics Review Board of the University Medical Center Groningen has approved the study (METc 2021/072). The results of this study will be disseminated via peer-reviewed publications and scientific presentations at national and international conferences. TRIAL REGISTRATION NUMBER: Netherlands Trial Register (NL9261).