Definition, Burden, and Predictors of HIV-Associated Wasting and Low Weight in the OPERA Cohort

作者：Michael Wohlfeiler, Rachel Palmieri Weber, Laurence Brunet, Javeed Siddiqui, Michael Harbour, Amy Phillips, Brooke Hayward, Jennifer S Fusco, Ricky K Hsu, Gregory Fusco · 发表于：AIDS Research and Human Retroviruses · 年份：2023 · DOI：10.1089/aid.2023.0048 · 被引用次数：8 · 研究领域：HIV-related health complications and treatments、HIV/AIDS Research and Interventions、HIV/AIDS drug development and treatment

We aimed to describe the prevalence, incidence, and predictors of HIV-associated wasting (HIVAW)/low weight among people with HIV (PWH) in the United States. We conducted an observational, clinical cohort analysis, utilizing prospectively collected electronic health record data obtained from the Observational Pharmaco-Epidemiology Research & Analysis (OPERA ® ) cohort. HIVAW/low weight included a wasting or low body–mass index (BMI)/underweight diagnosis (ICD codes and title search) or BMI <20 kg/m 2 . Prevalence was estimated among adult PWH in care from 2012 to 2015 and 2016 to 2020. Incidence from January 1, 2016, to October 31, 2021, was estimated using univariate Poisson regression among eligible PWH without prior HIVAW/low weight. Demographic and clinical predictors of incident HIVAW/low weight were included in multivariable logistic regression models, stratified by antiretroviral therapy (ART) experience. The period prevalence of HIVAW/low weight was 12% in both 2012–2015 and 2016–2020. Among 67,119 PWH without any prior HIVAW/low weight, 7% experienced incident HIVAW/low weight a median 64 months from HIV diagnosis. In multivariable regression models, similar predictor patterns were observed among ART-naïve and ART-experienced PWH without any prior HIVAW/low weight: lower odds of HIVAW/low weight with older age, female sex, Black race, and Hispanic ethnicity and higher odds with Medicaid. Notably, there was a dose–response relationship between increasing Vetera...