Cortical and subcortical mapping of the allostatic-interoceptive system in the human brain using 7 Tesla fMRI

作者：Jiahe Zhang, Danlei Chen, Philip Deming, Tara Srirangarajan, Jordan E. Theriault, Philip A. Kragel, Ludger Hartley, Kent M. Lee, Kieran McVeigh, Tor D. Wager, Lawrence L. Wald, Ajay B. Satpute, Karen S. Quigley, Susan Whitfield‐Gabrieli, Lisa Feldman Barrett, Marta Bianciardi · 发表于：bioRxiv (Cold Spring Harbor Laboratory) · 年份：2023 · DOI：10.1101/2023.07.20.548178 · 被引用次数：18 · 研究领域：Functional Brain Connectivity Studies、Psychosomatic Disorders and Their Treatments、Advanced Neuroimaging Techniques and Applications

Abstract The brain continuously anticipates the energetic needs of the body and prepares to meet those needs before they arise, called allostasis. In support of allostasis, the brain continually models the sensory state of the body, called interoception. We replicated and extended a large-scale system supporting allostasis and interoception in the human brain using ultra-high precision 7 Tesla functional magnetic resonance imaging (fMRI) ( N = 90), improving the precision of subgenual and pregenual anterior cingulate topography combined with extensive brainstem nuclei mapping. We observed over 90% of the anatomical connections published in tract-tracing studies in non-human animals. The system also included regions of dense intrinsic connectivity broadly throughout the system, some of which were identified previously as part of the backbone of neural communication across the brain. These results strengthen previous evidence for a whole-brain system supporting the modeling and regulation of the internal milieu of the body.