Endoplasmic reticulum stress controls PIN-LIKES abundance and thereby growth adaptation

作者：Sascha Waidmann, Chloé Béziat, Jonathan Ferreira Da Silva Santos, Elena Feraru, Mugurel I. Feraru, Lin Sun, Seinab Noura, Yohann Boutté, Jürgen Kleine‐Vehn · 发表于：Proceedings of the National Academy of Sciences · 年份：2023 · DOI：10.1073/pnas.2218865120 · 被引用次数：21 · 研究领域：Plant Molecular Biology Research、Photosynthetic Processes and Mechanisms、Plant Reproductive Biology

Extreme environmental conditions eventually limit plant growth [J. R. Dinneny, Annu. Rev. Cell Dev. Biol. 35 , 1–19 (2019), N. Gigli-Bisceglia, C. Testerink, Curr. Opin. Plant Biol. 64 , 102120 (2021)]. Here, we reveal a mechanism that enables multiple external cues to get integrated into auxin-dependent growth programs in Arabidopsis thaliana . Our forward genetics approach on dark-grown hypocotyls uncovered that an imbalance in membrane lipids enhances the protein abundance of PIN-LIKES (PILS) [E. Barbez et al. , Nature 485 , 119 (2012)] auxin transport facilitators at the endoplasmic reticulum (ER), which thereby limits nuclear auxin signaling and growth rates. We show that this subcellular response relates to ER stress signaling, which directly impacts PILS protein turnover in a tissue-dependent manner. This mechanism allows PILS proteins to integrate environmental input with phytohormone auxin signaling, contributing to stress-induced growth adaptation in plants.