Caffeic acid supplementation ameliorates intestinal injury by modulating intestinal microbiota in LPS-challenged piglets

作者：Xiaobin Wen, Fan Wan, You Wu, Lei Liu, Yueping Liu, Ruqing Zhong, Liang Chen, Hongfu Zhang · 发表于：Food & Function · 年份：2023 · DOI：10.1039/d3fo02286b · 被引用次数：50 · 研究领域：Biochemical effects in animals、Animal Nutrition and Physiology、Gut microbiota and health

. Meanwhile, CA supplementation improved the systemic and colonic inflammation responses, oxidative stress, and apoptosis induced by LPS. CA supplementation improved the alpha diversity and structure of the intestinal microbiota by increasing the abundance of beneficial microbiota. Additionally, it was found that it improves metabolic disorders of colonic bile acids (BAs) and short-chain fatty acids (SCFAs) in LPS-challenged piglets, including an increase in primary BAs and isovalerate. In conclusion, CA supplementation could enhance intestinal integrity and barrier function by modifying intestinal microbiota and its metabolites, which could lead to a reduction in inflammatory responses and oxidative stress and ultimately enhanced growth performance in piglets.