Reversible transformation of peptide assembly between densified-polysarcosine-driven kinetically and helix-orientation-driven thermodynamically stable morphologies

作者：Mohamed S. Elafify, Toru Itagaki, Nermeen A. Elkasabgy, Sinar Sayed, Yoshihiro Ito, Motoki Ueda · 发表于：Biomaterials Science · 年份：2023 · DOI：10.1039/d3bm00714f · 被引用次数：9 · 研究领域：Supramolecular Self-Assembly in Materials、Lipid Membrane Structure and Behavior、Polydiacetylene-based materials and applications

peptide assembly undergoes a reversible vesicle-nanotube transformation following a time course at room temperature and a heat treatment above 80 °C. Using membrane fluidity analysis with DPH and TMA-DPH and evaluating the environment surrounding the PSar side chain with NMR, we clarify that the vesicle was in a kinetically stable state driven by the dehydrated PSar chain, while the nanotube was in a thermodynamically stable state.