Dietary flavonoids intake contributes to delay biological aging process: analysis from NHANES dataset

作者：Wenmin Xing, Wenyan Gao, Zhenlei Zhao, Xiaogang Xu, Hongyan Bu, Huili Su, Genxiang Mao, Jun Chen · 发表于：Journal of Translational Medicine · 年份：2023 · DOI：10.1186/s12967-023-04321-1 · 被引用次数：70 · 研究领域：Phytoestrogen effects and research、Phytochemicals and Antioxidant Activities、Bioactive Compounds in Plants

BACKGROUND: Diet may influence biological aging and the discrepancy (∆age) between a subject's biological age (BA) and chronological age (CA). We aimed to investigate the correlation of dietary flavonoids with the ∆age of organs (heart, kidney, liver) and the whole body. METHOD: A total of 3193 United States adults were extracted from the National Health and Nutrition Examination Survey (NHANES) in 2007-2008 and 2017-2018. Dietary flavonoids intake was assessed using 24-h dietary recall method. Multiple linear regression analysis was performed to evaluate the association of dietary flavonoids intake with the ∆age of organs (heart, kidney, liver) and the whole body. BA was computed based on circulating biomarkers, and the resulting ∆age was tested as an outcome in linear regression analysis. RESULTS: The ∆age of the whole body, heart, and liver was inversely associated with higher flavonoids intake (the whole body ∆age β = - 0.58, cardiovascular ∆age β = - 0.96, liver ∆age β = - 3.19) after adjustment for variables. However, higher flavonoids intake positively related to renal ∆age (β = 0.40) in participants with chronic kidney disease (CKD). Associations were influenced by population characteristics, such as age, health behavior, or chronic diseases. Anthocyanidins, isoflavones and flavones had the strongest inverse associations between the whole body ∆age and cardiovascular ∆age among all the flavonoids subclasses. CONCLUSION: Flavonoids intake positively contributes to dela...