Design, synthesis, and biological evaluation of novel pyrimidin-2-amine derivatives as potent PLK4 inhibitors

作者：Yanli Xue, Shuyi Mu, Pengkun Sun, Yin Sun, Nian Liu, Yu Sun, Lin Wang, Dongmei Zhao, Maosheng Cheng · 发表于：RSC Medicinal Chemistry · 年份：2023 · DOI：10.1039/d3md00267e · 被引用次数：7 · 研究领域：Signaling Pathways in Disease、Microtubule and mitosis dynamics、Cancer Mechanisms and Therapy

> 145 min), and low risk of DDIs. At the cellular level, it presented excellent antiproliferative activity against breast cancer cells. Taken together, these results suggest that compound 8h has potential value in the further research of PLK4-targeted anticancer drugs.