OX40L-Armed Oncolytic Virus Boosts T-cell Response and Remodels Tumor Microenvironment for Pancreatic Cancer Treatment

作者：Shiyu Liu, Fan Li, Qiongqiong Ma, Mingjuan Du, Haoran Wang, Yiping Zhu, Li Deng, Wenrui Gao, Chunlei Wang, Yanqin Liu, Zhuoqian Zhao, Huanzhen Liu, Ruikun Wang, Yujie Tian, Manli Hu, Yajuan Wan, Wenyi Lu, Meng Zhang, Mingfeng Zhao, Youjia Cao, Hongkai Zhang, Wei Wang, Hui Wang, Yuan Wang · 发表于：Theranostics · 年份：2023 · DOI：10.7150/thno.83495 · 被引用次数：56 · 研究领域：Virus-based gene therapy research、CAR-T cell therapy research、Cancer Research and Treatments

OV-mOX40L converted the immunosuppressive tumor immune microenvironment to a more activated state, remodeled the stromal matrix, and enhanced T cell response. OV-mOX40L significantly prolonged the survival of PDAC mice, either as a monotherapy or in combination with synergistic antibodies. Thus, this study provides a multimodal therapeutic strategy for pancreatic cancer treatment.