Cobalt-Catalyzed Enantioselective Cross-Electrophile Couplings: Stereoselective Syntheses of 5–7-Membered Azacycles

作者：Zhaoming Ma, Wenqiang Xu, Yun‐Dong Wu, Jianrong Steve Zhou · 发表于：Journal of the American Chemical Society · 年份：2023 · DOI：10.1021/jacs.3c02829 · 被引用次数：36 · 研究领域：Catalytic C–H Functionalization Methods、Radical Photochemical Reactions、Catalytic Cross-Coupling Reactions

Cobalt complexes of chiral pyrox ligands catalyzed enantioselective reductive couplings of nonconjugated iododienes with aryl iodides or alkenyl bromides. The reaction enabled stereoselective syntheses of 5-7-membered azacycles carrying quaternary stereocenters. Mechanistically, cross-electrophile selectivity originated from selective coupling of alkylcobalt(I) complexes generated after cyclization with aryl iodides.