IL-6 mediates the hepatic acute phase response after prerenal azotemia in a clinically defined murine model

作者：Kayo Okamura, Sizhao Lu, Zhibin He, Chris Altmann, John R. Montford, Amy S. Li, M. Scott Lucia, David J. Orlicky, Mary C.M. Weiser‐Evans, Sarah Faubel · 发表于：American Journal of Physiology-Renal Physiology · 年份：2023 · DOI：10.1152/ajprenal.00267.2022 · 被引用次数：5 · 研究领域：Acute Kidney Injury Research、Chronic Kidney Disease and Diabetes、Dialysis and Renal Disease Management

Prerenal azotemia (PRA) accounts for a third of acute kidney injury (AKI) cases yet is rarely studied in preclinical models. We developed a clinically defined murine model of prerenal azotemia characterized by a 75% decrease in measured glomerular filtration rate (GFR), return of measured glomerular filtration rate to baseline with resuscitation, and absent tubular injury. Numerous systemic effects were observed, such as increased plasma interleukin-6 (IL-6) and upregulation of the hepatic acute phase response.