Are haematopoietic stem cell transplants stem cell transplants, is there a threshold dose of CD34-positive cells and how many are needed for rapid posttransplant granulocyte recovery?

作者：Junren Chen, Robert Peter Gale, Yahui Feng, Yu Hu, Saibing Qi, Xueou Liu, Huaiping Zhu, Xiaowen Gong, Wei Zhang, Huilan Liu, Zimin Sun · 发表于：Leukemia · 年份：2023 · DOI：10.1038/s41375-023-01973-2 · 被引用次数：10 · 研究领域：Hematopoietic Stem Cell Transplantation、Chronic Lymphocytic Leukemia Research、T-cell and B-cell Immunology

It is widely-believed recovery of bone marrow function after a haematopoietic cell transplant arises from pluripotent haematopoietic stem cells (HSCs; hence haematopoietic stem cell transplant) [ 1 ], that numbers of CD34-positive cells in a graft are an accurate proxy for numbers of HSCs [ 2 , 3 ], that dose of CD34-positive cells should be quantified by body weight and that there is a threshold dose of CD34-positive cells required for successful posttransplant bone marrow recovery [ 4 , 5 , 6 , 7 , 8 , 9 ].