Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota

作者：Wei Huang, Hui Chen, Qi Zhuang He, Weidang Xie, Zanlin peng, Qiang Ma, Qiaobing Huang, Zhongqing Chen, Yanan Liu · 发表于：Food & Function · 年份：2023 · DOI：10.1039/d3fo01684f · 被引用次数：66 · 研究领域：Ferroptosis and cancer prognosis、MicroRNA in disease regulation、Circular RNAs in diseases

in the gut were observed under NOB administration, suggesting that NOB might modulate the gut microbiota composition of septic mice. Furthermore, gut microbiota ablation by antibiotic treatment partly reversed the protective effects of NOB on sepsis. FMT also confirmed that NOB inhibited ferroptosis and activated Nrf2 signalling in SALI mice by modulating the gut microbiota. These results revealed that, by modulating the gut microbiota, NOB attenuated ferroptosis in septic liver injury through upregulating Nrf2-Gpx4. Our findings provide novel insights into microbiome-based therapeutic approaches for sepsis.