A temperature-regulated bioorthogonal reaction to target lysine: Hemiacetal pharmacophore in genipin irreversibly binds with UCP2, inhibiting mitochondrial thermogenesis

作者：Fukui Shen, Wen Yang, Kaixue Zhang, Yanting Jiao, Jing Cui, Yuanyuan Hou, Gang Bai · 发表于：Chinese Chemical Letters · 年份：2023 · DOI：10.1016/j.cclet.2023.108203 · 被引用次数：9 · 研究领域：Adipose Tissue and Metabolism、Mitochondrial Function and Pathology、Biochemical effects in animals