Serum cold-inducible RNA-binding protein (CIRP) levels as a prognostic indicator in patients with acute ischemic stroke

作者：Mingming Li, Min Yao, Kangmei Shao, Xueyang Shen, Yongnan Li, Zhaoming Ge · 发表于：Frontiers in Neurology · 年份：2023 · DOI：10.3389/fneur.2023.1211108 · 被引用次数：8 · 研究领域：Thermal Regulation in Medicine、RNA regulation and disease、Adipose Tissue and Metabolism

Background Acute ischemic stroke (AIS) is the leading cause of morbidity and mortality among cerebrovascular diseases. While animal studies have suggested a correlation between cold-inducible RNA-binding protein (CIRP) serum levels and the severity and prognosis of cerebral infarction, there has been a lack of research exploring this association in humans with cerebral infarction. Materials and methods A total of 148 patients diagnosed with AIS within 7 days from symptom onset were included in this study. Comprehensive information regarding the patients' basic demographics, medical history, clinical parameters, the severity of cerebral infarction, and serum CIRP levels was collected. Follow-up data were obtained through telephonic interviews or by reviewing clinical notes for 3 months after the patients were discharged to assess the functional outcomes of treatment. Results The findings of this study demonstrated a significant increase in serum CIRP levels during the early stages of AIS, followed by a gradual decline after 3 days. Significant differences were observed in the serum CIRP levels between the 1-day group and the 4–7 day group ( P < 0.0047), as well as between the 2–3 day group and the 4–7 day group ( P < 0.0006). Moreover, a significant positive correlation was observed between the serum CIRP levels and the severity of cerebral infarction. Higher serum CIRP levels were associated with more severe National Institutes of Health Stroke Scale scores ( P ...