The trigger for pancreatic disease: NLRP3 inflammasome

作者：Tianming Liu, Qiang Wang, Zhiwei Du, Yin Lu, Jiachen Li, Xianzhi Meng, Dongbo Xue · 发表于：Cell Death Discovery · 年份：2023 · DOI：10.1038/s41420-023-01550-7 · 被引用次数：29 · 研究领域：Inflammasome and immune disorders、Pancreatitis Pathology and Treatment、Diabetes and associated disorders

NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a complex regulatory mechanism, and its pro-inflammatory function plays an important role in pancreatic diseases. In this literature review, we summarize the activation mechanism of NLRP3 and analyze its role in each of the four typical pancreatic diseases. Through this article, we provide a relatively comprehensive summary to the researchers in this field, and provide some targeted therapy routes.