Clinical and Demographic Factors Associated With COVID-19, Severe COVID-19, and SARS-CoV-2 Infection in Adults

作者：Deborah Theodore, Angela R Branche, Lily Zhang, Daniel S. Graciaa, Madhu Choudhary, Timothy Hatlen, Raadhiya Osman, Tara M Babu, Samuel T. Robinson, Peter B. Gilbert, Dean Follmann, Holly Janes, James G. Kublin, Lindsey R. Baden, Paul Goepfert, Glenda Gray, Beatriz Grinsztejn, Karen L. Kotloff, Cynthia L. Gay, Brett Leav, Jacqueline M. Miller, Ian Hirsch, Jerald Sadoff, Lisa M. Dunkle, Kathleen M. Neuzil, Lawrence Corey, Ann R. Falsey, Hana M. El Sahly, Magdalena E. Sobieszczyk, Yunda Huang, COVID-19 Prevention Network (CoVPN), Atoya Adams, Eric N. Miller, Bruce G. Rankin, Steven Shinn, Marshall Nash, S Green, Colleen Jacobsen, Jayasree Krishnankutty, Sikhongi Phungwayo, Richard Glover, Stacy Slechta, Troy Holdeman, Robyn Hartvickson, Amber Grant, Terry L. Poling, Terry D. Klein, Thomas Klein, Tracy Klein, William Smith, Richard Gibson, Jennifer Winbigler, Elizabeth Parker, Priyantha N. Wijewardane, Eric Bravo, Jeffrey Thessing, Michelle Maxwell, Amanda Horn, Catherine Healy, Christine Akamine, Laurence Chu, R. Michelle Chouteau, Michael J. Cotugno, George H. Bauer, Greg Hachigian, Masaru Oshita, Michael Cancilla, Kristen Kiersey, William Seger, Mohammed Antwi, Allison Green, Anthony Kim, Michaël Desjardins, Jennifer Johnson, Amy C Sherman, Stephen R. Walsh, Judith Borger, Nafisa Saleem, Joel Solis, Martha Medina, Westly Keating, Edgar García, Cynthia Bueno, Nathan Segall, Douglas Denham, Thomas Weiss, Ayoade Avworo, Parke Hedges, Cynthia Strout, Rica Santiago, Yvonne Davis, Patty Howenstine, Alison Bondell, Kristin J. Marks, Tina Wang, Timothy Wilkin, Mary Vogler, Carrie D. Johnston, Michele P. Andrasik, Jessica Andriesen, Gail Broder, Niles Eaton, Huub G. Gelderblom, Rachael McClennen, Nelson L. Michael, Merlin Robb, Carrie Sopher, Vicki E. Miller, Fredric Santiago, Blanca Gomez, Insiya Valika, Amy Starr, Valeria D Cantos, Sheetal Kandiah, Carlos del Rı́o, Nadine Rouphael, Srilatha Edupuganti, Evan J. Anderson, Andrés Camacho-González, Satoshi Kamidani, Christiana A. Rostad, Meghan Teherani, David Diemert, Elissa Malkin, Marc Siegel, Afsoon Roberts, Gary L. Simon, Bindu Balani, Carolene Stephenson, Steven M. Sperber, Cristina Cicogna, Marcus Zervos, Paul E. Kilgore, Mayur Ramesh, Erica Herc, Kate Zenlea, Abram H. Burgher, Ann Marie Milliken, Joseph D. Davis, Brendan Levy, Sandra Kelman, Matthew W. Doust, Denise Sample, Sandra K. Erickson, Shane G. Christensen, Christopher Matich, James Longe, John Witbeck, James T. Peterson, Alexander M. Clark, Gerald Kelty, Issac Pena-Renteria, Michael J. Koren, Darlene Bartilucci, Alpa V. Patel, Carolyn Tran, C Kennelly, Robert Brownlee, Jacob Coleman, Hala Webster, Carlos Fierro, Natalia Leistner, Amy Thompson, Celia González, Lisa A. Jackson, Janice Suyehira, Milton Haber, Maria M. Regalado, Veronica Procasky, Alisha Lutat, Carl Griffin, Ripley R. Hollister, Jeremy Brown, Melody Ronk, Wayne L. Harper, Lisa Cohen, Lynn Eckert, Matthew Hong, Rambod Rouhbakhsh, Elizabeth Danford, John Asher Johnson, Richard Calderone, Shishir Khetan, Oyebisi Olanrewaju, Nan Zhai, Kimberly Nieves, Allison O'Brien, Paul S. Bradley, Amanda Lilienthal, Jim Callis, Adam Brosz, Andrea Clement, Whitney West, Luke Friesen, Paul Cramer, Frank Eder, Ryan Little, Victoria Engler, Heather Rattenbury-Shaw, David J. Ensz, Allie Oplinger, Brandon Essink, Jay Meyer, Frederick Raiser, Kimberly D. Mueller, Keith Vrbicky, Charles Harper, Chelsie Nutsch, Wendell Lewis, Cathy Laflan, Jordan L. Whatley, Nicole Harrell, Amie Shannon, Crystal Rowell, Christopher Dedon, Mamodikoe Makhene, Gregory Gottschlich, Kate Harden, Melissa Gottschlich, Mary Smith, Richard Powell, Murray Kimmel, Simmy Pinto, Timothy P. Vachris, Mark Hutchens, Stephen R. Daniels, Margaret Wells, Mimi Van Der Leden, Peta-Gay Jackson-Booth, Mira Baron, Pamela Kane, Shannen Seversen, Mara Kryvicky, Julia S. Lord, Jamshid Saleh, Matthew Miles, Rafael Lupercio, John McGettigan, Walter Patton, Riemke M Brakema, Karin Choquette, Jonlyn McGettigan, Judith L. Kirstein, Marcia Bernard, Mary Beth Manning, Joan Rothenberg, Toby Briskin, Denise Roadman, Sharita Tedder-Edwards, Howard I. Schwartz, Surisday Mederos, Shobha Swaminathan, Amesika N. Nyaku, Tilly Varughese, Michelle DallaPiazza, Sharon E. Frey, Irene Graham, Getahun Abate, Daniel F. Hoft, Leland N. Allen, Leslie A. Edwards, William S. Davis, Jessica M. Mena, Mark E. Kutner, Jorge Caso, Maria Hernandez Moran, Marianela Carvajal, Janet Méndez, Larkin T. Wadsworth, Michael Adams, Leslie Iverson, Joseph L. Newberg, Laura Pearlman, Paul J. Nugent, Michele D. Reynolds, Jennifer Bashour, Robert L. Schmidt, Neil P. Sheth, Kenneth Steil, Ramy J. Toma, William C. Kirby, Pink Folmar, Samantha Williams, Paul Pickrell, Stefanie Mott, Carol Ann Linebarger, Hussain Malbari, David Pampe, Veronica G. Fragoso, Lisa Holloway, Cecilia McKeown-Bragas, Teresa Becker, Barton G. Williams, William P. Jones, Jesse L. Clark, Steven Shoptaw, Michele Vertucci, Will Hernandez, Stephen A. Spector, Amaran Moodley, Jill Blumenthal, Lisa Stangl, Karen Deutsch, Kathleen M. Mullane, David Pitrak, Cheryl Nuss, Judy Pi, Carl J. Fichtenbaum, Margaret V. Powers‐Fletcher, Michelle Saemann, Sharon Kohrs, Thomas Campbell, Andrew Lauria, Jose Castillo Mancilla, Hillary Dunlevy, Richard Novák, Andrea Wendrow, Scott Borgetti, Ben Ladner, Matthew B. Laurens, Lisa Chrisley, Cheryl Young, Susanne Doblecki‐Lewis, María L. Alcaide, Jose Armando Gonzales Zamora, Stephen Morris, David A. Wohl, Joseph Eron, Ian Frank, Debora Dunbar, David Metzger, Florence Momplaisir, Judith M. Martin, Alejandro Hoberman, Timothy R. Shope, Gysella Muñiz, Richard Rupp, Amber Stanford, Megan Berman, Laura Porterfield, Michael Lewis, Elham Ghadishah, Joseph Yusin, Mai Pham, C. Buddy Creech, Shannon L. Walker, Stephanie Rolsma, Robert J. Samuels, Isaac Thomsen, Spyros A. Kalams, Greg Wilson, Gregg Lucksinger, Kevin Parks, Ryan Israelsen, Jaleh Ostovar, Kary Kelly, Jeffrey S. Overcash, Hanh Chu, Kia Lee, Luis I. De La Cruz, Steve Clemons, Elizabeth Everette, Suzanna Studdard, Gowdhami Mohan, Stefanie Tyson, Alyssa-Kay Peay, Danyel Johnson, Gregory Feldman, May-Yin Suen, Jacqueline Muenzner, Joseph Boscia, Farhan Siddiqui, John W. Sanders, James E. Peacock, Julio Nasim, Michael Levin, Julie Hussey, Marcy Kulic, Mark M. McKenzie, Teresa Deese, Erica Osmundsen, Christy Sweet, Valentine M. Ebuh, Elwaleed Elnagar, Georgette Ebuh, Genevieve Iwuala, Laurie J. Han-Conrad, Todd Simmons, Denis Tarakjian, Jeremy Ackermann, Mark Adams, José O. Alemán, Mohamed Al‐Ibrahim, David R. Andes, Jeb Andrews, Roberto C. Arduino, Martín Bäcker, Diana Badillo, Emma Bainbridge, Teresa A. Batteiger, José A. Bazan, Roger Bedimo, Jorge A. Benítez, Annette R. Bennett, David I. Bernstein, Kristin Bialobok, Rebecca Boas, Judith Brady, Cynthia Brown, Catherine A. Bunce, Robert S. Call, Wesley Campbell, Ellie Carmody, Christopher Carpenter, Steven E. Carsons, Marvin Castellon, Mario Castro, Hannah Catan, Jennifer Chang, Mouna G. Chebib, Corey M. Chen, Margaret Harris Cheng, Brian Chow, Annie Ciambruschini, Joseph P. Connor, James H. Conway, Maureen Cooney, Marcel E. Curlin, Claudia Rodríguez, Jon F. Dedon, Emily Degan, Michelle Dickey, Craig Dietz, Jennifer L Dong, Brenda Dorcely, Michael P. Dubé, Carmel B. Dyer, Benjamin Eckhardt, Edward F. Ellerbeck, Evan Ewers, Amy Falk, Brittany Feijoo, Uriel R. Felsen, Tom Fiel, David Fitzpatrick, Charles Fogarty, Stacy Ford, Lina M. Forero, Elizabeth Formentini, Doris Franco-Vitteri, Robert W. Frenck, Elie Gharib, Suzanne Gharib, Rola G. Rucker, James N. Goldenberg, Luis H. González, Brett Gray, Rusty Greene, Robert Grossberg, Juan V. Guanira, Alfredo Gilberto Guerreros Benavides, Clint C. Guillory, Shauna Gunaratne, David Halpert, Holli Hamilton, William R. Hartman, Sheryl L. Henderson, Ramin S. Herati, Laura Hernandez Guarin, Robin Hilder, Ken Ho, Leila S Hojat, Sybil Hosek, Jeffrey M. Jacobson, Melanie Jay, Diane Johnson, Kathleen S. Jones, Edward C. Jones‐López, Jessica Justman, Scott Kahney, Lois Katz, Melinda Katz, Daniel Kaul, Michael C. Keefer, Ashley Kennedy, Jennifer Knishinsky, Laura Kogelman, Susan L. Koletar, Angelica C Kottkamp, Maryrose Laguio‐Vila, Raphael J. Landovitz, Jessica L. Lee, Albert Liu, Eneyda Giuvanela Llerena Zegarra, Anna S. Lok, J. E. J. Lovell, Ronald Lubelchek, John Lucaj, Gary J. Luckasen, Annie Luetkemeyer, Njira Lugogo, Janine Maenza, Carlos Malvestutto, Monica Mauri, Ryan C. Maves, Kenneth H. Mayer, Michael J. McCartney, Margaret McCort, M. Juliana McElrath, Meredith McNairy, Fernando L. Merino, Eric A. Meyerowitz, C.L. Mitchell, Cynthia L. Monaco, Sauda Muhammad, Sigridh Muñoz-Gómez, Sonal S. Munsiff, Paul Nee, Nicole L. Nollen, Asif Noor, Claudio Nuñez Lagos, Jason F. Okulicz, Patrick A. Oliver, Jessica Ortega, Steven C. Palmer, Lalitha Parameswaran, Purvi Parikh, Susan Parker, Reza Parungao, J. Pavie, Rebecca Pellett Madan, Henry Peralta, Jennifer Petts, Kristen K. Pierce, E. Javier Pretell Alva, Lawrence J. Purpura, Vanessa Raabe, Sergio E. Recuenco, Tamara Richards, Sharon A. Riddler, Barbara Rizzardi, Rachel Rokser, Charlotte-Paige Rolle, Adam B. Rosen, Jeffrey B. Rosen, Lena R. Freese, Marı́a Elena Santolaya, Linda M. Schipani, Adam J. Schwartz, Tiffany Schwasinger‐Schmidt, Hyman Scott, Beverly E. Sha, Shivanjali Shankaran, Adrienne E. Shapiro, Stephan C. Sharp, Bo Shopsin, Matthew Sims, Stephanie Skipper, Derek M. Smith, Michael J. Smith, Mohammad Mahdee Sobhanie, Brit Sovic, Stephanie Sterling, Rob Striker, Karla Beatriz Tafur Bances, Kawsar R. Talaat, Edward Tavel, Hong‐Van Tieu, Christian Tomaszewski, Ryan Tomlinson, Juan Pablo Torres, Julián A. Torres, John J. Treanor, Sade Tukuru, Robert J. Ulrich, Gregory Utz, Veronica Viar, Roberto Viau, Edward E. Walsh, Mary C. Walsh, Emmanuel B. Walter, Jessica L. Weidler, Yi H. Wu, Kinara S. Yang, Juan Luis Yrivarren Giorza, Arthur L. Zemanek, Kevin Zhang, Barry S. Zingman, Richard L. Gorman, Carmen A. Paez, Edith Swann, Simbarashe Takuva, Alexander L. Greninger, Pavitra Roychoudhury, Robert W. Coombs, Keith R. Jerome, Flora Castellino, Xiaomi Tong, Corrina Pavetto, Teletha Gipson, Tina Tong, Marina Lee, James Zhou, Michael P. Fay, Kelly McQuarrie, Chimeremma Nnadi, Obiageli Sogbetun, Nina Ahmad, Ian De Proost, Cyrus Hoseyni, Paul Coplan, Najat Khan, Peter Ronco, Dawn Furey, Jodi Meck, Johan Vingerhoets, Boerries Brandenburg, Jerome Custers, Jenny Hendriks, Jarek Juraszek, Anne Marit de Groot, Griet Van Roey, Dirk Heerwegh, Ilse Van Dromme, Jorge F. Méndez Galván, Monica B. Carrascal, Adriana Sordo Duran, Laura Guerrero, Martha Cecilia Gómora Madrid, Alejandro Quintín Barrat Hernández, Sharzhaad Molina Guizar, Denisse Alejandra González Estrada, Silvano Omar Martínez Pérez, Zindy Yazmín Zárate Hinojosa, Guillermo Miguel Ruiz-Palacios, Aurelio Cruz-Valdéz, Janeth Pacheco-Flores, Anyela Lara, Secia Díaz-Miralrio, María José Reyes Fentanes, Jocelyn Zuleica Olmos Vega, Daniela Pineda Méndez, Karina Cano Martínez, Winniberg Stephany Alvarez León, Vida Veronica Ruiz Herrera, Eduardo Gabriel Vázquez Saldaña, Laura Julia Camacho Choza, Karen Sofia Vega Orozco, Sandra Janeth Ortega Domínguez, Jorge A. Chacón, Juan J. Rivera, E. Cutz, Maricruz E. Ortegón, María I. Rivera, David Browder, Cortney Burch, T. H. Moye, P. K. Bondy, Lesley H. Browder, Rickey D. Manning, James Willard Hurst, Rodney E. Sturgeon, Phil Wakefield, John A. Kirby, James Andersen, Szheckera Fearon, Rosa Negron, Amy Medina, John M. Hill, Vivek Rajasekhar, Hayes Williams, L. Cade, Rhodna Fouts, Connie Moya, Corey G. Anderson, Naomi Devine, James M. Ramsey, Ashley Perez, David Tatelbaum, Michael A. Jacobs, Kathleen Menasche, Vincent Mirkil, Peter Winkle, Amina Z. Haggag, Michelle Haynes, M.C. Castro Villegas, Sabina Raja, Robert Riesenberg, Stanford Plavin, Mark Lerman, Leana Woodside, Marı́a Cecilia Johnson, Catherine Healy, Jennifer A. Whitaker, Wendy A. Keitel, Robert L. Atmar, Gary Horwith, Robín Masón, Lisa Johnson, Tambra Dora, Deborah Murray, Logan Ledbetter, Beverly Ewing, Kathryn E. Stephenson, Chen Sabrina Tan, Rebecca Zash, Jessica L. Ansel, Kate Jaegle, Caitlin J. Guiney, Jeffrey A. Henderson, Marcia O’Leary, Kendra Enright, Jill Kessler, Pete Ducheneaux, Asha Inniss, Donald M. Brandon, William B. Davis, Daniel T. Lawler, Yaa Oppong, Ryan P. Starr, Scott N. Syndergaard, Rozeli Shelly, M. Majumder, Danny Sugimoto, Jeffrey R. Dugas, Dolores Rijos, Sandra Waller Shelton, Stephan Hong, Howard Schwartz, Nelia Sánchez-Crespo, Jennifer Schwartz, Terry Piedra, Barbara Corral, Carmen Medina, Michael Dever, Mitul Shah, Michael S. Delgado, Tameika Scott, Lisa Usdan, Lora J. McGill, Valerie Arnold, Carolyn Scatamacchia, Codi M. Anthony, Rajan Merchant, Anelgine C. Yoon, Janet E. Hill, Lucy Ng-Price, Teri Thompson-Seim, Ronald Ackerman, Jamie Ackerman, Florida Aristy, Nzeera Ketter, Jon M. Finley, Mildred Stull, Monica Murray, Zainab Rizvi, Sonia Guerrero, Yogesh K. Paliwal, Amit Paliwal, Sarah Gordon, Bryan C. Gordon, Cynthia Montano-Pereira, Chris Galloway, Candice Montros, Lily Aleman, Samira Shairi, Wesley Van Ever, G.H. Freeman, Esther L. Harmon, Marshall A. Cross, Kacie Sales, Catherine Q. Gular, Matthew J. Hepburn, Nathan L. Alderson, Shana Harshell, Siham Mahgoub, Celia Maxwell, Thomas A. Mellman, Karl M. Thompson, Glenn Wortman, Jeff Kingsley, April Pixler, LaKondria Curry, Sarah Afework, Austin D. Swanson, Jeffry Jacqmein, Maggie Ann Bowers, Dawn Robison, Victoria Mosteller, Janet Garvey, Mary Easley, Rebecca J. Kurnat, Raymond Cornelison, Shanda Gower, William Schnitz, Destiny S. Heinzig-Cartwright, Derek Lewis, Fred E. Newton, Aeiress Duhart, Breanz Watkins, B.A. Ball, Jill York, Shelby Pickle, David B. Musante, William P. Silver, Linda R. Belhorn, Nicholas A. Viens, David Dellaero, Priti Patel, Kendra Lisec, Beth Safirstein, Luz Marina Zapata, Lazaro Gonzalez, Evelyn Quevedo, Farah Gillan Irani, Joseph A. Grillo, Amy Potts, Julie White, Patrick A. Flume, Gary Headden, Brandie D. Taylor, Ashley Warden, Amy Chamberlain, Robert Jeanfreau, Susan Jeanfreau, Paul Matherne, Amy Caldwell, Jessica Stahl, Mandy Vowell, Lauren Newhouse, Vladimir Berthaud, Zudi-Mwak Takizala, Genevieve Beninati, Kimberly Snell, Sherrie Baker, James R. Walker, Tavane Harrison, Meagan Miller, Janet Otto, Roni Gray, C. D. Wilson, Tiffany Nemecek, Hannah K. Harrington, Sally Eppenbach, Wendell Lewis, Tana Bourgeois, Lyndsea Folsom, Gregory Holt, Mehdi Mirsaeidi, Rafael Calderon, Paola Lichtenberger, Jalima Quintero, Becky Martinez, Lilly Cheng Immergluck, Erica Johnson, Austin Chan, Norberto Fas, LaTeshia Thomas-Seaton, Saadia Khizer, Jonathan Staben, Tatiana Beresnev, Maryam Jahromi, Mary Marovich, Julia Hütter, Martha Nason, Julie E. Ledgerwood, John R. Mascola, Mark Leibowitz, Fernanda Morales Berstein, M. Delgado, Rosario Sánchez, Norma Vega, Germán Áñez, Gary Albert, Erin Coston, Chinar Desai, Haoua Dunbar, Mark Eickhoff, Jenina Garcia, Margaret Kautz, Angela Lee, Maggie Lewis, Alice McGarry, Irene McKnight, J C Nelson, Patrick Newingham, Patty Price-Abbott, Patty Reed, Diana Vegas, Bethanie Wilkinson, Katherine R. Smith, Wayne Woo, Iksung Cho, Gregory M. Glenn, Filip Dubovsky, David L. Fried, Lynne A. Haughey, Ariana C. Stanton, Lisa Stevens Rameaka, David Rosenberg, Lee Tomatsu, Viviana Andrea Dosman González, Millie Manalo, Bernard Grunstra, D.J. Quinn, Phillip Claybrook, Shelby Olds, Amy Dye, Kevin D. Cannon, Mesha M. Chadwick, B. Jordan, Morgan Hussey, Hannah Nevarez, Colleen F. Kelley, Michael Chung, Caitlin A. Moran, Paulina A. Rebolledo, Christina Bacher, Elizabeth Barranco-Santana, Jessica Rodriguez, Rafael Mendoza‐Meroño, Karen Ruperto, Odette Olivieri, Enrique Ocaña, Paul E. Wylie, Renea Henderson, Natasa Jenson, Fan Yang, Amy S. Kelley, Kenneth Finkelstein, David Beckmann, Tanya Hutchins, Sebastian Garcia Escallon, Kristen Johnson, Teresa S. Sligh, Parul Desai, Vincent Huynh, Carlos Lopez, Erika Mendoza, Jeffrey Adelglass, Jerome G. Naifeh, Kristine J. Kucera, Waseem Chughtai, Shireen H. Jaffer, Matthew Davis, Jennifer A. Foley, Michelle L. Burgett, Tammi Shlotzhauer, Sarah M. Ingalsbe-Geno, Daniel M. Duncanson, Kelly Kush, Lori A. Nesbitt, Cora Sonnier, Jennifer McCarter, Michael B. Butcher, James Fry, Donna Percy, Karen Freudemann, Bruce C. Gebhardt, Padma N. Mangu, Debra B. Schroeck, Rajesh K. Davit, Gayle D. Hennekes, Benjamin J. Luft, Melissa A. Carr, Sharon Nachman, Alison Pellecchia, Candace Smith, Bruno Valenti, Maria I. Bermudez, Noris Peraita, Ernesto Delgado, Alicia Arrazcaeta, Natalie Ramirez, Carmen Amador, Horacio Marafioti, Lyly Dang, Lauren Clement, Jennifer N. Berry, Mohammed Allaw, Georgettea Geuss, Chelsea Miles, Zachary S. Bittner, Melody Werne, Cornell Calinescu, Shannon Rodman, Joshua Rindt, Erin Cooksey, Kristina Harrison, Deanna Cooper, Manisha Horton, Amanda Philyaw, Will Jennings, Hilario Alvarado, Michele Baka, M Regalado, Linda Murray, Sherif Naguib, Justin Singletary, S Richmond, Sarah Omodele, Emily Oppenheim, Reuben Martinez, Victoria Andriulis, Léonard Singer, Jeanne Blevins, Meagan Thomas, Christine Hull, Isabel Pereira, Gina Rivero, Tracy Okonya, Frances Downing, Paulina Miller, Margaret Rhee, Katherine Stapleton, Jeffrey A. Klein, Rosamond Hong, Suzanne K. Swan, Tami Wahlin, Elizabeth L. Bennett, Amy Salzl, Sharine Phan, Jewel J. White, Amanda Occhino, Ruth Paiano, Morgan McLaughlin, Elisa Swieboda, Veronica Garcia-Fragoso, María Gabriela Becerra, Toni White, Christine B. Turley, Andrew McWilliams, Tiffany Esinhart, Natasha Montoya, Shamika Huskey, Leena Paul, Karen T. Tashima, Jennie Johnson, Marguerite A. Neill, Martha Sanchez, Natasha Rybak, Maria D. Mileno, Stuart H. Cohen, Mónica Vallejo Ruiz, Dean M. Boswell, Elizabeth E. Robison, Trina L. Reynolds, Sonja Neumeister, Carmen Zorrilla, Juana Rivera, Jessica Ibarra, Iris Garcia‐Martínez, Dianca Sierra, Wanda Ramon, Suzanne Fiorillo, Rebecca Pitotti, Victoria R. Anderson, Jose Castillo Mancilla, Nga Le, Patricia Winokur, Dilek İnce, Theresa Hegmann, Jeffery L. Meier, Jack T. Stapleton, Laura Stulken, Monica A. McArthur, Andrea A. Berry, Milagritos Tapia, E. Adrianne Hammershaimb, Toni Robinson, Rosa MacBryde, Susan Kline, Joanne Billings, Winston Cavert, Les B. Forgosh, Timothy W. Schacker, Tyler D. Bold, Dima Dandachi, Taylor Nelson, Andres Bran, Grant Geiger, S. Hasan Naqvi, Diana F. Florescu, Richard Starlin, David Kline, Andrea Zimmer, Anum Abbas, Natasha Wilson, Joseph Eron, Michael Sciaudone, A. Lina Rosengren, John S. Kizer, Sarah E. Rutstein, Carina A. Rodriguez, Elizabeth Bruce, Claudia Espinosa, Lisa J. Sanders, Kami Kim, Denise Casey, Barbara S. Taylor, Thomas L. Patterson, Ruth S. Pinilla, Delia Bullock, Philip Ponce, Jan E. Patterson, R. Scott McClelland, Dakotah C. Lane, Anna Wald, Frank James, Elizabeth R. Duke, Kirsten Hauge, Jessica Heimonen, Erin A. Goecker, Yunda Huang, Youyi Fong, Carol A. Kauffman, Kathleen A. Linder, Kimberly Nofz, Andrew McConnell, Robert Buynak, Angella Webb, Taryn Petty, Stephanie Andree, Erica L. Sanchez, Nolan Mackey, Clarisse Baudelaire, Sarah Dzigiel, Adrienna Marquez, Kim Quillin, Michelle King, Vanessa Abad, Jennifer Knowles, Michael J. Waters, Karla Zepeda, Jordan Coslet, Dalia Tovar, Marian E. Shaw, Mark Turner, Cory J. Huffine, Esther S. Huffine, Julie A. Ake, Elizabeth Secord, Eric McGrath, Phillip D. Levy, Brittany Stewart, Charnell Cromer, Ayanna Walters, Grant Ellsworth, Caroline Greene, Sarah Galloway, Shashi N. Kapadia, Elliot DeHaan, Clint C. Wilson, J. Milligan, Danielle Raley, Joseph A. Bocchini, Bruce McClenathan, Mary Hussain, Evelyn Lomasney, Evelyn Hall, Sherry Lamberth, Christy Schmeck, Vickie Leathers · 发表于：JAMA Network Open · 年份：2023 · DOI：10.1001/jamanetworkopen.2023.23349 · 被引用次数：23 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies、Long-Term Effects of COVID-19

Importance: Current data identifying COVID-19 risk factors lack standardized outcomes and insufficiently control for confounders. Objective: To identify risk factors associated with COVID-19, severe COVID-19, and SARS-CoV-2 infection. Design, Setting, and Participants: This secondary cross-protocol analysis included 4 multicenter, international, randomized, blinded, placebo-controlled, COVID-19 vaccine efficacy trials with harmonized protocols established by the COVID-19 Prevention Network. Individual-level data from participants randomized to receive placebo within each trial were combined and analyzed. Enrollment began July 2020 and the last data cutoff was in July 2021. Participants included adults in stable health, at risk for SARS-CoV-2, and assigned to the placebo group within each vaccine trial. Data were analyzed from April 2022 to February 2023. Exposures: Comorbid conditions, demographic factors, and SARS-CoV-2 exposure risk at the time of enrollment. Main Outcomes and Measures: Coprimary outcomes were COVID-19 and severe COVID-19. Multivariate Cox proportional regression models estimated adjusted hazard ratios (aHRs) and 95% CIs for baseline covariates, accounting for trial, region, and calendar time. Secondary outcomes included severe COVID-19 among people with COVID-19, subclinical SARS-CoV-2 infection, and SARS-CoV-2 infection. Results: A total of 57 692 participants (median [range] age, 51 [18-95] years; 11 720 participants [20.3%] aged ≥65 years; 31 058 partic...