Multi-Omics Reveals the Impact of Exogenous Short-Chain Fatty Acid Infusion on Rumen Homeostasis: Insights into Crosstalk between the Microbiome and the Epithelium in a Goat Model

作者：Yongkang Zhen, Zanna Xi, Shaima Mohamed Nasr, Feiyang He, Mengli Han, Junliang Yin, Ling Ge, Yifei Chen, Yusu Wang, Wenjun Wei, Yihui Zhang, Mengzhi Wang · 发表于：Microbiology Spectrum · 年份：2023 · DOI：10.1128/spectrum.05343-22 · 被引用次数：33 · 研究领域：Ruminant Nutrition and Digestive Physiology、Reproductive Physiology in Livestock、Plant and fungal interactions

The consequences of massive exogenous supplementation of SCFAs on rumen microbial fermentation and rumen epithelium health remain an area that requires further exploration. In our study, we sought to investigate the specific impact of administering high doses of exogenous acetate, propionate, and butyrate on rumen homeostasis, with a particular focus on understanding the interaction between the rumen microbiome and epithelium. Importantly, our findings indicated that the massive infusion of these SCFAs did not induce rumen inflammation. Instead, we observed enhancements in antioxidant capacity, strengthening of rumen barrier function, and promotion of rumen papilla development, which were facilitated through interactions with specific rumen bacteria. By addressing existing knowledge gaps and offering critical insights into the regulation of rumen health through SCFA supplementation, our study holds significant implications for enhancing the well-being and productivity of ruminant animals.