Implementation and resource needs for long‐acting PrEP in low‐ and middle‐income countries: a scoping review

作者：Delivette Castor, Craig J. Heck, Daniela Quigee, Niharika Vasant Telrandhe, Kiran Yan Kui, Jiaxin Wu, Elizabeth Glickson, Kibret Yohannes, Sergio Torres‐Rueda, Fiammetta Bozzani, Kathrine Meyers, Jason Zucker, Justine Deacon, Katharine Kripke, Magdalena E. Sobieszczyk, Fern Terris‐Prestholt, Christine Y. Malati, Chris Obermeyer, Anita Dam, Katie Schwartz, Steven Forsythe · 发表于：Journal of the International AIDS Society · 年份：2023 · DOI：10.1002/jia2.26110 · 被引用次数：13 · 研究领域：HIV/AIDS Research and Interventions、Pneumocystis jirovecii pneumonia detection and treatment、Adolescent Sexual and Reproductive Health

INTRODUCTION: Several low- and middle-income countries (LMICs) are preparing to introduce long-acting pre-exposure prophylaxis (LAP). Amid multiple pre-exposure prophylaxis (PrEP) options and constrained funding, decision-makers could benefit from systematic implementation planning and aligned costs. We reviewed national costed implementation plans (CIPs) to describe relevant implementation inputs and activities (domains) for informing the costed rollout of LAP. We assessed how primary costing evidence aligned with those domains. METHODS: We conducted a rapid review of CIPs for oral PrEP and family planning (FP) to develop a consensus of implementation domains, and a scoping review across nine electronic databases for publications on PrEP costing in LMICs between January 2010 and June 2022. We extracted cost data and assessed alignment with the implementation domains and the Global Health Costing Consortium principles. RESULTS: We identified 15 implementation domains from four national PrEP plans and FP-CIP template; only six were in all sources. We included 66 full-text manuscripts, 10 reported LAP, 13 (20%) were primary cost studies-representing seven countries, and none of the 13 included LAP. The 13 primary cost studies included PrEP commodities (n = 12), human resources (n = 11), indirect costs (n = 11), other commodities (n = 10), demand creation (n = 9) and counselling (n = 9). Few studies costed integration into non-HIV services (n = 5), above site costs (n = 3), supp...