Metagenomic next-generation sequencing in the diagnosis of neurocysticercosis: A case report

作者：Wenbin Xu, Juan Fu, Xiao-Ju Yuan, Qingjie Xian, Lijun Zhang, Pingping Song, Zhi-Qing You, Cheng-Tan Wang, Qi‐Gang Zhao, Feng Pang · 发表于：World Journal of Clinical Cases · 年份：2023 · DOI：10.12998/wjcc.v11.i20.4912 · 被引用次数：5 · 研究领域：Parasitic infections in humans and animals、Parasitic Diseases Research and Treatment、Cerebrospinal fluid and hydrocephalus

BACKGROUND: The clinical symptoms and imaging manifestations of neurocysticercosis (NCC) are very different, and the difficulty and delay of clinical diagnoses may lead to an increase in mortality and disability. Rapid and accurate pathogen identification is important for the treatment of these patients. Metagenomic next-generation sequencing (mNGS) is a powerful tool to identify pathogens, especially in infections that are difficult to identify by conventional methods. CASE SUMMARY: reads, and the positive results of a cysticercosis antibody test confirmed the infection. Combined with the patient's clinical manifestations, the etiological evidence, and the imaging manifestation, the patient was finally diagnosed with NCC and he was prescribed dexamethasone, albendazole, neurotrophic drugs, and intracranial pressure reduction therapy. The headaches disappeared after anti-parasite treatment, and no associated symptoms recurred prior to the three- and six-month follow-up. CONCLUSION: As an accurate and sensitivity detection method, mNGS can be a reliable approach for the diagnosis of NCC.