Triquinane Sesquiterpene Glycosides from the Basidiomycete Antrodiella zonata

作者：Ming-Xuan Gao, Feng Wu, Si-Qiong Teng, He‐Ping Chen, Zheng-Hui Li, Juan He, Tao Feng, Ji‐Kai Liu · 发表于：Journal of Natural Products · 年份：2023 · DOI：10.1021/acs.jnatprod.3c00200 · 被引用次数：11 · 研究领域：Fungal Biology and Applications、Microbial Natural Products and Biosynthesis、Chemical synthesis and alkaloids

In our ongoing study of fungal bioactive natural products, 12 previously undescribed triquinane sesquiterpene glycosides, namely, antrodizonatins A–L ( 1 – 12 ), and four known compounds ( 13 – 16 ) have been obtained from the fermentation of the basidiomycete Antrodiella zonata . The structures were established unambiguously via extensive spectroscopic analysis and theoretical calculations of electronic circular dichroism spectra. This is the first report of triquinane sesquiterpene glycosides. Compounds 1, 5, and 12 displayed antibacterial activity against Staphylococcus aureus with MIC 50 values of 35, 34, and 69 μM, respectively.