Interventions for people with type 2 diabetes mellitus fasting during Ramadan

作者：Shaun Wen Huey Lee, Won Sun Chen, Renukha Sellappans, Shakirah Binti Md.Sharif, Maria‐Inti Metzendorf, Nai Ming Lai · 发表于：Cochrane Database of Systematic Reviews · 年份：2023 · DOI：10.1002/14651858.cd013178.pub2 · 被引用次数：6 · 研究领域：Dietary Effects on Health、Berberine and alkaloids research、Diet and metabolism studies

BACKGROUND: Fasting during Ramadan is obligatory for adult Muslims, except those who have a medical illness. Many Muslims with type 2 diabetes (T2DM) choose to fast, which may increase their risks of hypoglycaemia and dehydration. OBJECTIVES: To assess the effects of interventions for people with type 2 diabetes fasting during Ramadan. SEARCH METHODS: We searched CENTRAL, MEDLINE, PsycINFO, CINAHL, WHO ICTRP and ClinicalTrials.gov (29 June 2022) without language restrictions. SELECTION CRITERIA: Randomised controlled trials (RCTs) conducted during Ramadan that evaluated all pharmacological or behavioural interventions in Muslims with T2DM. DATA COLLECTION AND ANALYSIS: Two authors screened and selected records, assessed risk of bias and extracted data independently. Discrepancies were resolved by a third author. For meta-analyses we used a random-effects model, with risk ratios (RRs) for dichotomous outcomes and mean differences (MDs) for continuous outcomes with their associated 95% confidence intervals (CIs). We assessed the certainty of evidence using the GRADE approach. MAIN RESULTS: We included 17 RCTs with 5359 participants, with a four-week study duration and at least four weeks of follow-up. All studies had at least one high-risk domain in the risk of bias assessment. Four trials compared dipeptidyl-peptidase-4 (DPP-4) inhibitors with sulphonylurea. DPP-4 inhibitors may reduce hypoglycaemia compared to sulphonylureas (85/1237 versus 165/1258, RR 0.53, 95% CI 0.41 to 0...