Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology

作者：Elena Gabriela Chiorean, Marco Del Chiaro, Margaret A. Tempero, Mokenge Peter Malafa, Al B. Benson, Dana Backlund Cardin, Jared A. Christensen, Vincent M. Chung, Brian G. Czito, Mary E. Dillhoff, Timothy R. Donahue, Efrat Dotan, Christos K Fountzilas, Evan Scott Glazer, Jeffrey M. Hardacre, William G. Hawkins, Kelsey A. Klute, Andrew H. Ko, John W. Kunstman, Noelle K. LoConte, Andrew M. Lowy, Ashiq Masood, Cassadie Moravek, Eric K. Nakakura, Amol Kumar Narang, Lorenzo Nardo, Jorge V. Obando, Patricio Marcelo Polanco, Sushanth Reddy, Marsha Reyngold, Courtney L. Scaife, Jeanne Shen, Mark Joseph Truty, Charles M. Vollmer, Robert A. Wolff, Brian Matthew Wolpin, Beth A. McCullough, Senem Lubin, Susan D. Darlow · 发表于：Journal of the National Comprehensive Cancer Network · 年份：2023 · DOI：10.6004/jnccn.2023.0034 · 被引用次数：94 · 研究领域：Pancreatic and Hepatic Oncology Research、Hepatocellular Carcinoma Treatment and Prognosis、Colorectal Cancer Treatments and Studies

Ampullary cancers refer to tumors originating from the ampulla of Vater (the ampulla, the intraduodenal portion of the bile duct, and the intraduodenal portion of the pancreatic duct), while periampullary cancers may arise from locations encompassing the head of the pancreas, distal bile duct, duodenum, or ampulla of Vater. Ampullary cancers are rare gastrointestinal malignancies, and prognosis varies greatly based on factors such as patient age, TNM classification, differentiation grade, and treatment modality received. Systemic therapy is used in all stages of ampullary cancer, including neoadjuvant therapy, adjuvant therapy, and first-line or subsequent-line therapy for locally advanced, metastatic, and recurrent disease. Radiation therapy may be used in localized ampullary cancer, sometimes in combination with chemotherapy, but there is no high-level evidence to support its utility. Select tumors may be treated surgically. This article describes NCCN recommendations regarding management of ampullary adenocarcinoma.