Pyrosulfite-Involved Synthesis of Sulfides by Palladium-Catalyzed Decarboxylative Couplings

作者：Xiaokang Li, Bei Wei, Yanlong Gong, Chengyi Li, Xiaoting Liu, Bin Liu, Qingshan Li, Shurong Ban · 发表于：The Journal of Organic Chemistry · 年份：2023 · DOI：10.1021/acs.joc.3c00840 · 被引用次数：10 · 研究领域：Sulfur-Based Synthesis Techniques、Chemical Synthesis and Reactions、Radical Photochemical Reactions

The decarboxylative coupling using carboxylic acid and potassium metabisulfite, promoted by a palladium catalyst, is reported for the generation of sulfides. The coupling is performed using the easily available carboxylic acid and environmentally friendly inorganic sulfides as a divalent inorganic sulfur source. Not only aromatic acids but also aliphatic carboxylic acids are workable during the couplings. The method is applicable and practical to a scope of 20 examples and drug molecules.