The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer after curative surgery

作者：Qi Li, Tailai An, Jianbin Wu, Weiqi Lu, Yan Wang, Jia Li, Lina Yang, Yiqi Chen, Lizhu Lin, Zhenjiang Yang · 发表于：BMC Cancer · 年份：2023 · DOI：10.1186/s12885-023-11073-0 · 被引用次数：20 · 研究领域：Nutrition and Health in Aging、Enhanced Recovery After Surgery、Colorectal Cancer Screening and Detection

Abstract Background The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer has not been exhaustively investigated. Thus, the present study was performed to evaluate the effect of sarcopenia on the outcome of patients with left-sided colon and rectal cancer. Methods Patients with pathologically diagnosed stage I, II and III left-sided colon or rectal cancer who had undergone curative surgery between January 2008 and December 2014 were retrospectively reviewed. The psoas muscle index (PMI) identified by 3D-image analysis of computed tomographic images was the criterion used to diagnose sarcopenia. The cut-off value recommended by Hamaguchi (PMI value < 6.36 cm 2 /m 2 for men and < 3.92 cm 2 /m 2 for women) was adopted to confirm the diagnosis of sarcopenia. According to the PMI, each patient was divided into the sarcopenia group (SG) or the nonsarcopenia group (NSG). Then, the SG was compared with the NSG in terms of postoperative outcomes. Results Among the 939 patients included, 574 (61.1%) were confirmed to have preoperative sarcopenia. Initially, it was demonstrated that the SG was not significantly different from the NSG in terms of most baseline characteristics except for a lower body mass index (BMI) ( P < 0.001), a larger tumour size ( P < 0.001) and more weight loss (more than 3 kg in the last three months) ( P = 0.033). The SG had a longer hospital stay after surgery ( P = 0.040), more intraoperative blood transfusions ...