Practice Patterns of Spatially Fractionated Radiation Therapy: A Clinical Practice Survey

作者：Nina A. Mayr, Majid Mohiuddin, J.W. Snider, Hualin Zhang, Robert J. Griffin, Beatriz E. Amendola, Daniel S. Hippe, Naipy Pérez, Xiaodong Wu, Simon S. Lo, William F. Regine, Charles B. Simone · 发表于：Advances in Radiation Oncology · 年份：2023 · DOI：10.1016/j.adro.2023.101308 · 被引用次数：41 · 研究领域：Radiation Therapy and Dosimetry、Advanced Radiotherapy Techniques、Advances in Oncology and Radiotherapy

Purpose Spatially fractionated radiation therapy (SFRT) is increasingly used for bulky advanced tumors, but specifics of clinical SFRT practice remain elusive. This study aimed to determine practice patterns of GRID and Lattice therapy (LRT) based SFRT. Materials and Methods A survey was designed to identify radiation oncologists' practice patterns of patient selection for SFRT, dosing/planning, dosimetric parameter use, SFRT platforms/techniques, combinations of SFRT with conventional external beam radiation therapy (cERT) and multimodality therapies, and physicists' technical implementation, delivery and quality procedures. Data were summarized using descriptive statistics. Group comparisons were analyzed with permutation tests. Results The majority of practicing radiation oncologists (100% - US, 72.7% - global) considered SFRT an accepted standard-of-care radiotherapy option for bulky/advanced tumors. Treatment of metastases/recurrences and non-metastatic primary tumors, predominantly head and neck, lung cancer and sarcoma, was commonly practiced. In palliative SFRT, regimens of 15-18 Gy/1 fraction predominated (51.3%); and in curative-intent treatment of non-metastatic tumors 15 Gy/1 fraction (28.0%) and fractionated SFRT (24.0%) were most common. SFRT was combined with cERT commonly but not always in palliative (78.6%) and curative-intent (85.7%) treatment. SFRT–cERT time sequencing and cERT dose adjustments were variable. In curative-intent treatment, concurrent chemoth...