Transcriptional level of inflammation markers associates with short-term brain structural changes in first-episode schizophrenia

作者：Long‐Biao Cui, Xian-Yang Wang, Yu‐Fei Fu, Xiaofan Liu, Yongbin Wei, Shu‐Wan Zhao, Yue-Wen Gu, Jing-Wen Fan, Wen-Jun Wu, Hengfen Gong, Bochao Lin, Hong Yin, Fanglin Guan, Xiao Chang · 发表于：BMC Medicine · 年份：2023 · DOI：10.1186/s12916-023-02963-y · 被引用次数：31 · 研究领域：Tryptophan and brain disorders、Schizophrenia research and treatment、Stress Responses and Cortisol

BACKGROUND: Inflammation has been implicated in the pathology of schizophrenia and may cause neuronal cell death and dendrite loss. Neuroimaging studies have highlighted longitudinal brain structural changes in patients with schizophrenia, yet it is unclear whether this is related to inflammation. We aim to address this question, by relating brain structural changes with the transcriptional profile of inflammation markers in the early stage of schizophrenia. METHODS: Thirty-eight patients with first-episode schizophrenia and 51 healthy controls were included. High-resolution T1-weighted magnetic resonance imaging (MRI) and clinical assessments were performed at baseline and 2 ~ 6 months follow-up for all subjects. Changes in the brain structure were analyzed using surface-based morphological analysis and correlated with the expression of immune cells-related gene sets of interest reported by previous reviews. Transcriptional data were retrieved from the Allen Human Brain Atlas. Furthermore, we examined the brain structural changes and peripheral inflammation markers in association with behavioral symptoms and cognitive functioning in patients. RESULTS: Patients exhibited accelerated cortical thickness decrease in the left frontal cortices, less decrease or an increase in the superior parietal lobule and right lateral occipital lobe, and increased volume in the bilateral pallidum, compared with controls. Changes in cortical thickness correlated with the transcriptional level o...