3L, Three-Lactobacilli on Recovering of Microbiome and Immune-Damage by Cyclophosphamide Chemotherapy—A Pilot Experiment in Rats

作者：Shousong Yue, Zhenzhong Zhang, Fei Bian, Yan Zhang, Chen Gao, Youfeng Zhu, Jun Li, Jean‐François Picimbon · 发表于：Microbiology Research · 年份：2023 · DOI：10.3390/microbiolres14030059 · 研究领域：Gut microbiota and health、Digestive system and related health、Liver Disease Diagnosis and Treatment

We deal with various strains of Lactobacillus that can maintain the intestinal microbiome of rats treated with cyclophosphamide, an anticancer agent (chemotherapy). We use MiSeq and various types of statistical tests to prove that cyclophosphamide in rats alters the intestinal microbiome, favoring the growth of various fungi that are extremely harmful to intestinal metabolism. On the contrary, when Lactobacillus 3L is administered together with cyclophosphamide, we prove that the microbiome is preserved by having a much better intestinal metabolism.